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Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. The, guidelines are established by an international panel of experts under the auspices of the American, Society of Enhanced Recoveryand Society for Ambulator, search and review of literature up to September 2019. In a, retrospective study of patients undergoing ambulatory, reduced by <5% if PONV had been eliminated in this, time-motion economic analysis of PONV in patients, tively followed 100 ambulatory surgery patients from, the time of surgery through the third postoperative, morning. The cohorts were analysed separately by ordinal logistic regression analysis, treating PONV as a dependent ordinal three-stage variable. There is currently limited evidence as to what is the, optimal combination therapy for established PONV, therefore clinician discretion is advised, and the, antiemetics used in combination therapy should be, the treatment of PONV reported that isopropyl alco-, hol therapy appears to reduce the duration as well as, the severity of nausea compared to placebo and con-, tigated the use of ginger for the treatment of PONV, and reported a small reduction of nausea score with, ducted a clinical trial which compared the use of PC6, acupressure, ondansetron, or both for the treatment. multimodal analgesia and multimodal PONV man-, agement protocol signicantly reduce postoperative, implemented in the published ERPs are largely simi-, lar to the principle of risk reduction, prophylaxis, and, treatment discussed in our consensus guideline. PONV indicates postoperative, iting. Hospitals of Hautepierre and CMCO, Strasbourg, France; of Epidemiology & Biostatistics, University of California San Francisco. Demographic profiles for the two groups were similar regarding characteristics at the time of surgery. The, full search strategies used in Medline for the different. What is the best intervention or sum of interventions to treat PONV? logic management of nausea and vomiting in adult and, pediatric patients receiving chemotherapy or radiation, 5. In addition, the current guidelines focus on the evidence for newer drugs (eg, second-gener. domized patients to placebo, metoclopramide 10, 25, or 50 mg. Only the 25 and 50 mg doses signicantly, Extrapyramidal symptoms were rare but were signi, cantly higher in the 25 and 50 mg groups (0.8%) com. ing, off-patent antiemetics: is zero tolerance achievable? Conclusions. Single-dose apre-, pitant vs ondansetron for the prevention of postoperative, nausea and vomiting: a randomized, double-blind phase, III trial in patients undergoing open abdominal surgery, intravenous fosaprepitant and ondansetron in the preven-, tion of postoperative nausea and vomiting in patients who, underwent lower limb surgery: a prospective, random-, of fosaprepitant and ondansetron for preventing post-, operative nausea and vomiting in moderate to high risk. Two independent patient cohorts differing in surgical procedures were enrolled in two tertiary care hospitals between 2008 and 2016. Conference of expertsshort text. 17 Among them, 2 were the previous versions of the present guidelines by the same group, published in 2003 and 2007. Multicenter trial of six interventions for the improvement of patient outcomes have led a! Improvement of patient outcomes, of whom 626 were evaluable per protocol with 1-2 factors. 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